Disitamab vedotin combined with pyrotinib as salvage treatment in Her-2-amplified treatment refractory metastatic colorectal cancer: a case report

BackgroundHuman epidermal growth factor receptor 2 (HER-2) amplification has been identified in approximately 3% of patients with metastatic colorectal cancer (mCRC).Owing to the lack of Feature established anti-ERBB2 therapeutic approaches, mCRC patients with Her-2 amplification rarely receive targeted treatments.Moreover, conventional chemotherap

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A Comparison of Provision and Access to Inclusive Education for Children with Disabilities in a Metropolitan City and a Rural District in Telangana State, India

In response to international agreements, recent Indian legislation has raised expectations that all children, regardless of need or ability, Collections should gain access to formal education that is inclusive and addresses their social and learning needs.Initiatives designed to support the implementation of this legislation have been undertaken in

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Evaluating the Impact of Absorber Geometry on Solar Still Efficiency: A Comparative Study of Square and Round Absorbers

Solar stills have been used for many years in areas with limited access to fresh water, such as desert regions or remote locations.They are simple to construct using readily available materials and require no energy input other than sunlight.Additionally, solar stills are low-maintenance and can produce a significant amount of pure water with relat

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Research on the Effects of Various Intake Levels of Buckwheat on Intestinal Function and Intestinal Flora in Hypercholesterolemic Mice

The effect of diets containing different proportions of buckwheat on intestinal function of cholesterol absorption and excretion and intestinal microbiota in hypercholesterolemic mice were studied.The mice were divided into four groups where they were fed with AIN-93M standard diet (control group), a high-cholesterol diet (model group), a high-chol

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